Fungal pores feel the pull

Fungal pores feel the pull

Fungal pores feel the pull S teinberg et al. report that fungi use motor proteins to distribute their nuclear pores around the nuclear envelope. In animal cells, the nuclear lamina holds the nuclear pores in place, ensuring that they are evenly spaced. The lamina prevents nuclear pores from clustering, promoting import of cargoes through the pores and helping to organize the chromosomes, which ...

Kinetochores feel the pull

S uzuki et al. (1) take a close look at how kinetochores change shape when spindle microtubules tug on them. They fi nd that only part of the kinetochore stretches and identify a protein that might confer this ability. Kinetochores, which hook the fi bers of the mitotic spindle to chromosomes, are more than passive fasteners. Fashioned from more than 100 proteins, the structures are dynamic and...

Mitotic regulation of fungal cell-to-cell connectivity through septal pores involves the NIMA kinase

Intercellular bridges are a conserved feature of multicellular organisms. In multicellular fungi, cells are connected directly via intercellular bridges called septal pores. Using Aspergillus nidulans, we demonstrate for the first time that septal pores are regulated to be opened during interphase but closed during mitosis. Septal pore-associated proteins display dynamic cell cycle-regulated lo...

The Feel of Java

Pores in the Wall

Address correspondence to Shoichiro Tsukita, M.D., Ph.D., Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. Tel.: 81-75-753-4372. Fax: 81-75-753-4660. E-mail:htsukita @mfour.med.kyoto-u.ac.jp 1 Abbreviations used in this paper: CPE, Clostridium perfringens enterotoxin; TJ, tight junction. In vertebrates, tight junctions (TJs) 1 play a central ro...